Budding Yeast Model
Simulation:
Numerical solution of the mathematical model for the wild type budding yeast is shown.Simulations compared well with experimental observations.
For a culture growing exponentially at a MDT=90 min,
(1) Duration of cell cycle phases:
Cycle time, min | G1 length, min | S/G2/M, min | |
Daughter Cell | 97.5 (101.2)* | 42 (36) | 57 (64) |
Mother Cell | 81 (80) | 22 (28) | 59 (52) |
* Data for a wild type yeast diploid strain A364A D5 are obtained from Brewer et al., 1984, simulation results are shown in parenthesis.
(2) The relative amounts of cyclins and CKIs:
([Cln1]+[Cln2]) : (Clb5]+[Clb6]) : ([Clb1]+[Clb2]) : [Sic1] : [Cdc6]
=15 : 3.8 : 7.5 : 1 : 3 (in experiments)
=15 : 3.3 : 4.7 : 2.8 : 3.7 (in model).
Measurements are made by Cross et al., 2002, and Archambault et al., 2003.